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Lieutenant Reginald Barclay; Starfleet Systems diagnostic engineer. Barclay transferred to the U S.S. Enterprise-D from the U.S.S, Zhukov in 2366. Lieutenant Barclay was an extremely talented engineer, but was timid and awkward in social situations. Noted as having reclusive tendencies, Barclay compensated for his shyness by devising a rich fantasy life inside the Enterprise-D holodeck. In these fantasies, Barclay would re-create images of those crew mates in bizarre settings that he controlled. Engineer Geordi La Forge helped Barclay overcome the need for such escapes by encouraging Barclay's sense of self-worth. "Hollow Pursuits".
In
2367, Barclay was exposed to a broad-spectrum emission from a
Cytherian probe. The signal from the probe caused a dramatic increase
in Barclay's neurochemical activity, increasing his I.Q. to at least
1200. With this newly enhanced intelligence, Barclay designed and
built an innovative new computer interface system, as well as an
incredibly fast new warp drive. It was learned that the Cytherians
were reluctant to explore space themselves, so they resorted to this
technique to give others the ability to reach them. Although the
Enterprise-D contact with the Cytherians yielded valuable cultural
and scientific exchanges, Barclay's enhanced intelligence faded, and
with it the advanced warp drive technology was also lost. "The
Nth Degree".
Barclay had a strong phobia of traveling by transporter. He described his "mortal terror" of being dematerialized. Barclay concealed this fear to avoid jeopardizing his Starfleet career, but he spent many hours traveling aboard shuttlecraft in order to avoid being beamed. He ultimately faced his greatest fears during a rescue mission to the U.S.S. Yosemite in 2369, when he was threatened by quasi-energy microbes actually living in the transporter beam. "Realm of Fear".
Barclay helped Worf's son, Alexander Rozhenko, create a holodeck program called Ancient West just prior to Stardate 46271. "A Fistful of Datas".
Barclay was part of the engineering team that attempted to solve the problem of how to give the computer-generated intelligence, Professor James Moriarty, physical reality, when Moriarty held the ship hostage in 2369. "Ship in a Bottle".
Fond of
investigating the Starfleet Medical Database, Barclay often convinced
himself that he had contracted some rare and fatal disease. In 2370,
he visited sickbay, convinced that he was suffering from Terellian
Death Syndrome. Dr. Crusher assured him that he only had a mild case
of the Urodelean flu, and prescribed a Synthetic T-cell to allow his
body to fight the infection naturally. Unfortunately, the T-cell
caused some of Barclay's introns to mutate. These mutated introns,
once airborne, affected the entire crew, causing them to revert to
earlier evolutionary forms. Once the cause and cure of the disease
was found, Dr. Crusher named the syndrome after its first case,
Barclay's Protomorphosis 
Syndrome.
Barclay was one of the few persons aboard the Enterprise-D, besides
Data, that Spot seemed to like. "Genesis".
Lieutenant Barclay left the Enterprise-D and transferred to the Holoprogramming Center at Starfleet's Jupiter Station. He worked with Dr. Lewis Zimmerman on the engineering team that designed Starfleet's Emergency Medical Hologram program. Barclay tested the holographic doctor's interpersonal skills. In 2372, the holographic doctor aboard the Starship Voyager encountered a holographic representation of Barclay. "Projections" (VGR).
Barclay later transferred onto the new Enterprise-E and was on the ship in 2373 during its encounter with the Borg in Earth's past Zephram Cochrane was one of Barclay's heroes, and Barclay became star-struck when he met the scientist while in Montana in 2063. Star Trek: First Contact.
Barclay had an idea how to contact the Voyager but had trouble convincing his superior to allow the experiment. "Pathfinder".(VOY)