Star Trek: The Original Series

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Khan Noonian Sing; Genetically engineered human who attempted to gain control of the entire planet Earth in the 1990s during the Eugenics Wars. From 1992 to 1996, Khan was absolute ruler of more than a quarter of Earth, from South Asia through the Middle East. He was the last of the tyrants to be overthrown. Khan escaped in 1996 with a band of followers aboard the sleeper ship S.S. Botany Bay.
In 2267 the Starship Enterprise discovered the Botany Bay and awakened Khan and his people. Once awakened, Khan attempted to take over the Enterprise, but was thwarted. Captain Kirk exercised command prerogatives in dropping all charges when Khan agreed to be exiled to planet Ceti Alpha V to start a new life. "Space Seed"
Khan and his followers remained on Ceti Alpha V for several years, until they were accidentally discovered by a scientific reconnaissance party from the Starship Reliant in 2285. Khan commandeered the Reliant and ransacked the nearby Regula I Space Laboratory, stealing the experimental Genesis Device. Khan, along with his followers and the crew of the Reliant, were killed when the Genesis Device exploded while aboard the Reliant. Star Trek II: The Wrath of Khan.

Following the Eugenics Wars, Earth governments, and later the Federation, outlawed genetic engineering in hopes of preventing the creation of another Khan. "Doctor Bashir, I Presume?" (DS9).